Yes, there is some music I have never returned to. Steely Dan is one such example. I have all the albums on vinyl. I loved them all, but not felt it necessary to replace them with CD or download. I had listened to these frequently and feel I have 'exhausted the material'.
The same has applied to the Allman Bros Band, the Eagles, Neil Young, America, Marshall Tucker Band and more.
Even those that were 'extra-special' to me have been majorly neglected for the self same reason. eg: Grateful Dead, Little Feat & Traffic.
Having said that, the seemingly inexhaustible font of Grateful Dead live recordings has made a difference. After avoiding them for 18 or so months, this month I bought a 21 cd box of shows from 1971 that had been Radio Broadcasts. I have only listened to one show (3 cds) in its entirety. That is Harding Theatre SF 7/November/1971 which is worth the whole £21 I paid for the box.
The point is this includes performances I'd not not heard before, and some of which include improvisations that went somewhere unexpected. I was delighted and surprised all over again. Hell, I miss them.
I admit I have been a voracious consumer of music. I recently found a Poi Dog Pondering album called '7' that was a return to form (some later stuff had been f-ing awful) and a delight to hear. Most of this trend is me looking backward. Even current artists such as Los Lobos & Ry Cooder are long in the tooth. There again though, I have a couple of friends who have never moved on from their teenage favourites.
But 50% of my current music listening is from SongStuff members, which has become valuable to me. I listened to a piece by Steve Mueske yesterday. It engaged me immediately. Its unhelpful to have expectations when approaching new music, though we all do to some extent.
This is a pretty damn good place. I'm going to drop a coin in the poorbox right now.